The results of this study showed that TNF-α and IL-6 alleviated significantly with time between 3 days and 14 days after surgery, and TNF-α and IL-6 in the study group were significantly lower than those in the control group, and the incidence rate of postoperative complications in the study group was 6.67% significantly lower than that in the control group, suggesting that the combination of red ointment and traditional Chinese medicine fumigation bath can reduce the inflammatory reaction and reduce the possibility of postoperative complications after anal fistula surgery. This evidence concerns the gene IL6 and Anal fistula.