The biomarker alfa fetoprotein (AFP) has poor sensitivity and specificity due to a false positive rate, but when used in conjunction with the US, it had significantly higher sensitivity in the detection of early-stage HCC than the US alone, the other biomarker that is also used in the detection of HCC is des-gamma-carboxy-prothrombin (DCP) [10]. This evidence concerns the gene DES and hepatocellular carcinoma.