TNF and liver disorder: After the liver injury, mast cells are activated, the number of mast cells in the liver increases, and the degranulation of mast cells release a variety of mediators such as histamine, heparin, tryptase, chymase, TGF-β1, TNF-α, ILs, cytokines, basic fibroblast growth factor (bFGF) and leukotrienes (LT) B4, LTD4, prostaglandins, etc. (Lappalainen et al., 2004; Galli et al., 2008; Halova et al., 2012; Bulfone-Paus and Bahri, 2015; Komi et al., 2020), which can regulate the progression of liver disease (Figure 1).