In this regard, the Dahl salt-sensitive rat, an important model of salt-sensitivity, demonstrated HTN and proteinuria after a salt load, which was associated with elevated Rac1 activation, MR signaling and upregulation of both SGK1 and ENaC, in comparison to Dahl salt-resistant rats (Farjah et al., 2003; Aoi et al., 2007; Shibata et al., 2011; Pavlov and Staruschenko, 2017). The gene discussed is NR3C2; the disease is hypertensive disorder.