In line with this, mice with severe combined immune deficiency (SCID) or recombination-activating gene 1 (RAG-1) gene deficiency (absence of B and T cells), demonstrated resistance to HTN, vascular abnormalities, renal damage, and water and salt retention, caused by Ang II or salt (Guzik et al., 2007; Crowley et al., 2010; Marvar et al., 2010; Mattson et al., 2013). Here, RAG1 is linked to hypertensive disorder.