Likewise, mice lacking IFNγ−/− were also protected from HTN after chronic aldosterone (Garcia et al., 2012) or Ang II infusion (Trott et al., 2014; Kamat et al., 2015b) or during the high salt-feeding phase of N (gamma)-nitro-L-arginine methyl ester/High salt (L-NAME/HS) (Itani et al., 2016a). The gene discussed is IFNG; the disease is hypertensive disorder.