In SCD mice penises, treatment with molecules that increase the bioavailability of NO/cGMP reduced the expression of the gp91phox, 3-NT, and 4-HNE, as well as reversed priapism (Bivalacqua et al., 2013; Lagoda et al., 2014; Silva et al., 2016b; Musicki et al., 2018, 2020). This evidence concerns the gene CYBB and Priapism.