The existence of mutations that disrupt the KEAP1/NRF2 regulatory system in cancer cells sheds new light on the observed “oncogene-directed” increased expression of NRF2 whereby the expression of KRAS, BRAF, and MYC oncogenes in primary murine cells was found to cause an increase in NRF2 mRNA and protein levels[85]. This evidence concerns the gene NFE2L2 and cancer.