Pro-apoptotic proteins including Bax, cytochrome C, caspase 9a, cleaved caspase 3, and cleaved caspase 9 were observed to be downregulated, while anti-apoptotic proteins Bcl-2 and Bcl-XL were upregulated in CD44+ GC cells compared with CD44- GC cells[108]. The gene discussed is CYCS; the disease is gastric cancer.