ABCB1 and cancer: Three major ABC transporters, including P-glycoprotein (P-gp/MDR1/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2), have been found in various drug-resistant cancer cell lines and tissues and studied extensively for their correlation to multidrug resistance (MDR)[97].