For example, the V600E mutation in v-raf murine sarcoma viral oncogene homolog B1 (BRAF) is found in several tumors, including metastatic colorectal cancer[51], melanoma[52,53], papillary thyroid cancer[54], etc. The V600E variant of BRAF is targetable with drugs such as vemurafenib, dabrafenib, and trametinib, and its presence can drive the choice of therapy[55]. This evidence concerns the gene BRAF and melanoma.