EWSR1 and Ewing sarcoma: Moreover, 85% of Ewing sarcomas harbor a specific chromosomal translocation [t(11:22)(q24:q12)] leading to the fusion of the N-terminal portion of Ewing sarcoma gene (EWS) with the C-terminal portion of Friend leukemia integration 1 transcription factor (FLI1), which encodes for a chimeric protein that behaves as a transcription factor and modulates a plethora of cellular processes, eventually leading to malignant transformation[17].