Recently, a meta-analysis showed that high levels of VEGF are also associated with advanced tumor stage and metastasis, with negative consequences in terms of survival; high VEGF expression is implicated in worse disease-free survival (odds ratio = 0.25, 95%CI: 0.11-0.58, P = 0.001) and overall survival (odds ratio = 0.22, 95%CI: 0.13-0.35, P ≤ 0.001)[119]. Here, VEGFA is linked to neoplasm.