Stemness in CSCs is favored by autophagy in some types of tumors, e.g., breast cancer, pancreatic ductal adenocarcinoma, colon cancer, etc. Osteosarcoma CD271+ cells have stem cell characteristics that seem dependent on autophagic activity, with an increased expression of essential autophagy genes such as Beclin1, LC3B, Atg5, and Atg7 compared to CD271 OS cells. The gene discussed is NGFR; the disease is malignant colon neoplasm.