Metabolic reprograming induced by hypoxia/ HIF-1α is characterized by glycolytic enzyme lactate dehydrogenase A (LDH-A) and accelerated glycolysis (Warburg effect) that contribute to lactate accumulation, affecting tumor T cell infiltration and cytokine productions, inhibits the NK and CD8+T cells cytotoxic activity and favors MDSCs infiltration. This evidence concerns the gene HIF1A and neoplasm.