The most frequent gene altered in this pathology is tumor suppression gene P53, and mutations in other cancer drivers such as RB1, ATRX2, DLG23, RUNX2, WRN, RECQL4, CDKN2A/B, BLM, PTEN, and PI3K/AKT/mTOR pathway members are described in OS tumors. This evidence concerns the gene RB1 and neoplasm.