Due to its conserved signaling gatekeeper function as a major network bottleneck, SIAHON/OFF expression is well-positioned to serve as a direct readout of tumor-driving EGFR/K-RAS/MEK/MAPK pathway activation (ON)/inactivation (OFF) in TNBC [Figure 1B][76,77,85,89]. This evidence concerns the gene EGFR and neoplasm.