KRAS and cancer: Due to the extraordinary conservation of EGFR/RAS/MAPK/SIAH signaling pathway across metazoan species, the molecular insights and core principles gleaned from Drosophila EGFR/RAS/SINA studies have shed light on the evolutionarily conserved principles and fundamental aspects of mammalian EGFR/K-RAS/MAPK/SIAH signaling pathway, and guided anti-EGFR/K-RAS/MAPK/SIAH drug development in human cancer[77,79-85].