BRCA2 and posterior cortical atrophy: Analysis of whole-exome and transcriptome sequencing of mCRPC biopsies revealed that alterations in DNA-damage repair (DDR) genes including BRCA2, BRCA1, and ATM occur at higher frequencies in mCRPC (19.3%) than in primary PCa, of which 12.7% of the samples were identified with loss of BRCA2[43].