PLK4 and clear cell renal carcinoma: Meanwhile, we screened the expression profiles of renal clear cell carcinoma and its corresponding paired paraneoplastic tissues included in the TCGA database, followed by the analysis of the differential expression of PLK4 in tumor and its corresponding paired paraneoplastic tissues by R language, and the results showed that PLK4 was highly expressed in tumor tissues compared with paracancerous tissues (Figure 1(d)).