The results showed that the PLK4 expression was positively correlated with the level of infiltration of cancer-associated fibroblast (rho = 0.269, p = 4.61e − 09), neutrophils (rho = 0.528, p = 1.86e − 34), myeloid dendritic cells (rho = 0.409, p = 5.33e − 20), active CD4+ T cells (rho = 0.292, p = 1.66e − 10), CD8+ T cells (rho = 0.358, p = 2.01e − 15), endothelial cells (rho = 0.166, p = 3.40e − 04), monocytes (rho = 0.418, p = 6.17e − 21), macrophage M1 (rho = 0.45, p = 2.60e − 24), and macrophage M2 (rho = −0.297, p = 8.10e − 11). Here, CD4 is linked to cancer.