There are reports that some HLA class II molecules were associated with viral infection, such as infectious mononucleosis, and with neuroinflammatory activity and progression in patients with chronic hepatitis C.27, 28Although DRB1*13:02 alone did not increase the risk of DRESS development in our study, it could have some facilitating roles in the development of DRESS because virus reactivations are involved in the pathogenesis of DRESS.29 The gene discussed is HLA-DRB1; the disease is viral infectious disease.