To assess the difference in the genetic predisposition of HLA alleles according to the SCAR phenotypes, we compared the phenotype frequency of the HLA alleles presenting at least 30% and 2‐folds difference between the DRESS and SJS/TEN groups: A*24:02, DRB1*13:02, A*02:06, C*04:01 and DRB1*04:06 met the criteria. Here, HLA-DRB1 is linked to toxic epidermal necrolysis.