TREM2 and Alzheimer disease: In addition, multi-omics analysis of CD11b+ small EVs from the parietal cortex of AD subjects vs. control and normal/low pathology cases revealed a significant reduction in the abundance of the homeostatic microglia markers P2RY12 and TMEM119, mirrored by an increase of DAM markers Ferritin Heavy Chain 1 (FTH1) and TREM2, while senescence was one of the top pathways controlled by four miRNAs found significantly upregulated in AD microglial EVs by transcriptome analysis (Cohn et al., 2021).