TREM2 and Alzheimer disease: Moreover, small EVs released by microglia-like cells derived from iPSC with heterozygous R47H mutation in TREM2 (R47Hhet EVs), a mutation linked to late onset AD, shows alterations in cytokine/chemokine content and contain proteins linked to negative regulation of transcription and metabolic processes, in line with reported metabolic deficits of mutant microglia (Mallach et al., 2021b).