Taking advantage of a novel adeno-associated virus (AAV) based model exhibiting rapid tau propagation and the P301S mouse model of tauopathy, they proved that microglial EVs propagate tau in the enthorinal-hippocampal circuit, mediating a reduction of neuron excitability and an increase in neuron apoptosis, while either microglia depletion or inhibition of EV release suppressed tau propagation (Asai et al., 2015). Here, MAPT is linked to tauopathy.