MAPT and Alzheimer disease: Crotti et al. (2019) observed that Bridging INtegrator 1 (BIN1), an adaptor protein that regulates lipid membrane dynamics, whose gene mutation are highly associated to Late Onset AD, favors the spreading of AD pathological protein tau via EVs. However, targeted deletion of BIN1 from microglia decreased tau spreading in vivo only in male and not female PS19 mice.