Both Aβ and tau, the two neurotoxic proteins hallmark of AD, and α-synuclein, hallmark of PD, have been found in myeloid EVs, released from microglia/macrophages, isolated from the CSF of AD/PD patients (Saman et al., 2012; Joshi et al., 2014; Guo et al., 2020). Here, MAPT is linked to Alzheimer disease.