In addition, multi-omics analysis of CD11b+ small EVs from the parietal cortex of AD subjects vs. control and normal/low pathology cases revealed a significant reduction in the abundance of the homeostatic microglia markers P2RY12 and TMEM119, mirrored by an increase of DAM markers Ferritin Heavy Chain 1 (FTH1) and TREM2, while senescence was one of the top pathways controlled by four miRNAs found significantly upregulated in AD microglial EVs by transcriptome analysis (Cohn et al., 2021). Here, P2RY12 is linked to Alzheimer disease.