SIRT1 and renal fibrosis: We interrogated three genes that were upregulated in the transcriptomic datasets of the soft hydrogel samples: (1) SIRT1 (Sirtuin 1), a histone deacetylase that is downregulated in valves from AVS patients compared to control,7 (2) KDM6A/B (lysine demethylase 6A and B), which are H3K27me3‐specific histone demethylases that protect against renal fibrosis,35 and (3) CREBBP (CREB‐binding protein), an acetyltransferase that protects against VIC calcification.36