This research found that blood GRB2 and IL-6 levels were considerably greater in patients with T2DM with CAS than in patients with T2DM without CAS, and that GRB2 was closely linked with HDL-C, IL-6, and Hs-CRP, which was similar with the findings of earlier animal model studies. Here, GRB2 is linked to type 2 diabetes mellitus.