Consistent with their report, we also found clues to a potential role of GRB2 in the regulation of glucose metabolism and insulin resistance, the results of this study showed that serum GRB2 levels were significantly higher in the T2DM group than in healthy controls, and serum GRB2 levels correlated with the duration of diabetes, HBA1c, FPG, and HOMA-IR. The gene discussed is GRB2; the disease is diabetes mellitus.