Coincidentally, in this study, the results of Spearman’s correlation analysis between perturbed gut flora genus, altered fecal metabolites, and lipid factors showed that AR-9 may directly upregulate the levels of citrulline and ornithine via the metabolic function of Clostridium to achieve a beneficial effect of treating HL (Figure 7). The gene discussed is AR; the disease is Hodgkins lymphoma.