We analyzed lung cancer cohorts with KRAS mutations (GSE31210) and found that higher hub gene levels (BUB1, BUB1B, NCAPG, CDC20, CDK1, KIF11) were significantly associated with worse OS in lung cancer patients with KRAS mutations (Figures 4D, E; Supplementary Figure S3D). This evidence concerns the gene BUB1 and lung carcinoma.