Proteasome inhibition may cause hypertension either because of an increased endogenous protein inhibitor of neuronal nitric oxide synthase, leading to decreased NO bioavailability in the paraventricular nucleus (Sharma et al., 2020), or from tyrosine hydroxylase upregulation and activation in the hypothalamus and brainstem (Congo Carbajosa et al., 2015), both resulting in increased sympathetic outflow. The gene discussed is TH; the disease is hypertensive disorder.