Indeed, according to the literature, there is a correlation between the histopathological evidence of renal fibrosis and profibrotic renal tissue markers, such as transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), and vascular endothelial growth factor A (VEGF-A) (Lopes et al., 2019). Here, CCN2 is linked to renal fibrosis.