Before PS matching, the patients who initiated SGLT-2i were older, more likely to be men, more likely to have ischemic heart disease or myocardial infarction, and more likely to have received a filled prescription for metformin; GLP-RA initiators had higher HbA1c level, had higher Charlson comorbidity index, were more likely to have diagnosis associated with obesity and CKD, and were more like to receive a filled prescription for insulin, DPP-4i and diuretics (Table 1, left). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.