Additionally, the intracellular domain of Pdpn can be bound by ezrin/radixin/moesin (ERM) proteins, leading to RhoA protein activation and epithelial-mesenchymal transition (EMT) in cancer cells (Krishnan et al., 2013; Krishnan et al., 2015; Suzuki-Inoue et al., 2017) (Figure 1). Here, PDPN is linked to cancer.