On the other hand, the Pdpn binding to ERM proteins through a juxtamembrane cluster of basic amino acids within the cytosolic domain, triggered the activation of RhoA GTPase-ROCK signaling, which eventually caused ezrin protein remodeling and promoted tumor metastasis and invasion (Martín-Villar et al., 2015; Petropoulos et al., 2018). This evidence concerns the gene PDPN and neoplasm.