First, IL-23 is able to differentiate T cells into pro-inflammatory cells TH17 (Korn et al., 2009), and second, IL-23 also has an effect on the T cell phenotype of SLE by inducing extrafollicular helper T cells (eTfh), driving B cell autoantibody production, while limiting IL-2 production and regulatory T cell (Treg) differentiation (Dai et al., 2017). The gene discussed is IL37; the disease is systemic lupus erythematosus.