Similarly, IL-23 is involved in mediating through the IL-23/TH-17 axis, activating signaling pathways such as JaK-STAT, PI3K/Akt and NF-κB, which drive chronic inflammation and autoimmunity by promoting TH17 cells differentiation, thus contributing to autoimmune diseases pathogenesis (Gaffen et al., 2014). The gene discussed is NFKB1; the disease is autoimmune disease.