IL-23, a cytokine belongs to the IL-12 family, has common characteristics of IL-12 family cytokines and also interacts with TH17 cells due to its unique cellular structure, regulates each other and forms the IL-23/TH-17 axis that affects autoimmune diseases such as psoriasis, SLE, RA, etc. IL-23 is of interest for its unique ability to convert activated T cells into brain pro-inflammatory and potentially self-mutilating effector cells, and targeting IL-23 remains an effective strategy for treating autoimmune diseases today. This evidence concerns the gene IL37 and systemic lupus erythematosus.