IL-23 functions in immune cells, affecting phagocytes and lymphocytes, and exerts autocrine effects on macrophages and dendritic cells, which in turn are closely related to autoimmune diseases (Singh et al., 2012), as a result, IL-23 plays a critical role in many autoimmune diseases development (Fragoulis et al., 2016) acting as a pro-inflammatory mediator and is expressed in a variety of autoimmune diseases like psoriasis, SLE, RA, IBD, etc, and differently (Tables 1–3) (Figure 1). This evidence concerns the gene IL23A and rheumatoid arthritis.