NFKB1 and autoimmune disease: The pathogenesis of autoimmune diseases is inextricably linked to the regulatory mechanisms of signaling pathways (Banerjee et al., 2017), with different signaling pathways between different cells; for example, the NF-κB signaling pathway is associated with T cells and can also inhibit B cell differentiation and development (Blanchett et al., 2021).