Mirsattari et al. (2012) confirmed that there is a positive correlation between serum IL-23 levels and ulcerative colitis (UC) (r = 0.27, p = 0.04) and directly related to the severity of the disease (mean IL-23 serum levels in patients with mild UC = 296.2 ± 51.2 pg/ml; moderate = 356.1 ± 142.9 pg/ml; severe = 399.3 ± 163.8 pg/ml, p = 0.04), putting out that IL-23 may become the marker of disease diagnosis. This evidence concerns the gene IL37 and ulcerative colitis.