High expression of STAT4 was significantly linked with the shortened OS in KIRP [HR = 1.50 (1.15, 1.96), p = 3.2e-3], KIPAN [HR = 1.30 (1.17, 1.45), p = 1.4e-6], and GBM [HR = 1.28 (1.07, 1.53), p = 7.4e-3], while lower STAT4 expression was significantly associated with lower OS rates in BRCA [HR = 0.88 (0.79, 0.98), p = 0.02], SARC [HR = 0.85 (0.74, 0.98), p = 0.02], SKCM [HR = 0.81 (0.75, 0.88), p = 1.3e-7], OV [HR = 0.88 (0.80, 0.96), p = 6.0e-3], and pancreatic adenocarcinoma (PAAD) [HR = 0.82 (0.69, 0.98), p = 0.03] (Figure 3D). Here, STAT4 is linked to glioblastoma.