S100A8 and neoplasm: γ/δ T cells also expressed less IL7R (which typically denotes more immature T cells), less IL10RA (which would render the cells resistant to IL10-mediated suppression by Tregs or MDSCs), less NFKBIA (demonstrating an increase in NFκB signalling associated with TCR engagement) and less S100A8/S100A9 (which promote accumulation of MDSCs in tumor tissue) (12).