Galina Deichman’s group discovered a link between Catalase-mediated protection of tumor cells from apoptotic ROS signaling and the H2O2-catabolizing phenotype (35) and confirmed that all transformed, and tumor cells produced significant amounts of extracellular superoxide anion, but the tumor cells were protected from ROS-mediated apoptosis induction via membrane-associated catalase expression. The gene discussed is CAT; the disease is neoplasm.