RASSF1 and lung cancer: The performance of the LungMe® (SHOX2 and RASSF1A) methylation assay when used for lung cancer detection on branchial aspirates was 75-81% sensitivity and 90-97% specificity (6, 7), and on FFPE tissue specimens, it had a sensitivity of 89.8% and a specificity of 90.4% (8).