Previous studies have shown that CD3D may serve as a prognostic maker of colon cancer, gastric cancer and other tumors (33, 34); CD3E can be used as a prognostic factor of lung cancer (35); the expression of CD247 was associated with many cancers, including gastric cancer, head and neck cancer and ovarian cancer (36–38). Here, CD3D is linked to malignant colon neoplasm.