In this study UV exposure is used as a research tool to investigate the effect of DNA damage on PRPF6 and PRPF31 mutant cells, but oxidative stress, from the high level of reactive oxygen species in the RPE cells, plays more of a role in retinal degeneration in vivo (Perdices et al., 2018; Murakami et al., 2020; Vingolo et al., 2022). This evidence concerns the gene PRPF6 and retinal degeneration.