In 2010, Graul-Neumann et al. detected a heterozygotic FBN1 c.8155_8156del variant in the exon 64 from a 27-year-old patient with congenital lipodystrophy, a progeroid facial appearance, and some signs of MFS (Graul-Neumann et al., 2010). This evidence concerns the gene FBN1 and Marfan syndrome.