MYC and neoplasm: The ssGSEA algorithm analysis, and later confirmed by GSVA, showed that cluster1 demonstrated a tendency to favor tumor proliferation and metastasis, as evidenced by the higher enrichment scores for gene sets of cell cycle regulators, cell cycle, DNA replication, EMT2, immune checkpoints, etc. Cluster1 pattern shows activity across a wide range of pathways and demonstrated high enrichment scores for G2M checkpoints, E2F targets, unfolded protein responses, MYC targets, oxidative photography, mitotic spindle, DNA replay, glycolysis, and other tumor progression–associated biological functions.