Notably, cluster1 was significantly enriched at G2M checkpoints, DNA repair, E2F targets, MTORC1 signaling, MYC targets, Glycolysis, EMT, TGF-β signaling, PI3K-AKT-MTOR signaling, and many other tumor progression–related pathways (Supplementary Figure S2). This evidence concerns the gene TGFB1 and neoplasm.