IL-25 is mainly produced by epithelial tuft cells because of the chemosensory receptors that these cells present (Borowczyk et al., 2021), linking with type 2 immunity by stimulating production of IL-13 by type 2 innate lymphoid cells which, in turn, induces signal transducer and activator of transcription 6-mediated intestinal alterations leading to resistance to infection (Fallon et al., 2006; Owyang et al., 2006; Zhao et al., 2010; Angkasekwinai et al., 2013, 2017; Cortés et al., 2017; Varyani et al., 2022). Here, IL25 is linked to infection.