Recent findings from Phf6 conditional knockout mouse models showed that the loss of Phf6 synergizes with leukaemic lesions, such as aberrant expression of TLX3, activating mutations in NOTCH1 or JAK3 activation to promote the onset of T‐ALL, demonstrating a tumour‐suppressive function for PHF6 in T‐ALL.7, 8, 9, 22, 23. Here, NOTCH1 is linked to acute lymphoblastic leukemia.