Multivariate analysis revealed that survival was adversely impacted by secondary AML (HR = 3.895, 95% CI 1.20, 12.63; p = 0.023), +8 (HR = 8.448, 95% CI 2.14, 33.42; p = 0.002), −7/7q‐ (HR = 7.318, 95% CI 1.28, 41.99; p = 0.026) and PHF6 mutation (HR = 8.910, 95% CI 3.51, 22.63; p < 0.001). The gene discussed is PHF6; the disease is acute myeloid leukemia.