NFKB1 and colitis: miRNAs are well-known mediators of cellular homeostasis,40 and are upregulated under stress-induced conditions, such as NF-κB activation in LPS-stimulated macrophages.41 In acute colitis models, EVs-miR-200b-3p was significantly increased, but in exogenous miRNA supplementation experiments, miR-200b-3p could significantly restore colonic inflammation symptoms.