Afatinib showed a favorable benefit in a phase II trial in patients with advanced refractory HER2-positive GEA, and phase II trials of afatinib in combination with paclitaxel as a second-line therapy for advanced/recurrent GEJ adenocarcinoma are ongoing (NCT02501603, NCT01522768) [101]. The gene discussed is ERBB2; the disease is gastroesophageal junction adenocarcinoma.