It has been observed that many clotting factors including fibrinogen, factor V, factor VII, factor VIII, factor X, factor XI, factor XII, kallikrein, and von Willebrand factor are elevated in DM patients [30, 31]; additionally, raised concentrations of other endothelium-derived mediators increase blood viscosity and promote platelet activation and adhesion [32]. Here, VWF is linked to diabetes mellitus.