The TAM family are implicated in regulating MDSC function, since increased MDSC expression of TYRO3, AXL and MERTK and their ligands was detected in a syngeneic mouse model of melanoma, and circulating MERTK+ and TYRO3+ MDSCs were more abundant in patients with metastatic melanoma [115]. The gene discussed is MERTK; the disease is melanoma.