Immune-enriched tumors may exhibit staining for PD-L1 on infiltrating immune and tumor cells [29, 41], and show abundance of type I and II IFN, IL12, IL23, IL1β, TNF, IL2, granzymes, CXCL9 and CXCL10 and other pro-inflammatory/effector cytokines [29, 41, 42]. This evidence concerns the gene CD274 and neoplasm.