RUNX2 and cleidocranial dysplasia 1: DFCs in patients with CCD showed significantly reduced abilities to induce osteoclast and osteoblast differentiation, as well as reduced matrix degradation, downregulated Runx2 expression, lower SATB2 expression, and higher expression of miR-31, whose transcription is inhibited by Runx2, when compared with healthy DFCs.