For example, in a combined sample of African American children from two cohorts (APIC and URECA), the rs113282230-T allele was associated with reduced lung function, a marker of asthma severity, lower blood neutrophil count, potentially reflecting rapid turnover due to increased trafficking to mucosal surfaces in response to epithelial signals, and low total serum IgE, reflecting a T2-low asthma phenotype [63]. This evidence concerns the gene IGHE and asthma.