GSDMA and asthma: The results described above highlighted two novel African-specific variants, rs113282230 and rs113571956, that were enriched on the asthma high-risk haplotype, were eQTLs for GSDMA, and mapped within a putative enhancer element that physically interacted with the promoter of GSDMA. These SNPs were in perfect LD in our sample (r2 = 1; Additional file 1: Fig. S7), so we arbitrarily selected one (rs113282230) for further analyses with clinical measures.