These seven traits represented the lung function (pre-bronchodilator %predicted forced expiratory capacity at 1 s [FEV1], n=607; FEV1/forced vital capacity [FVC], n=601; bronchodilator response, n=588), airway inflammation (fractional exhaled nitric oxide [FeNO], n=423), allergic (total immunoglobulin E [IgE], n=604), and immune cell (blood eosinophil count and blood neutrophil count, n=606) components of asthma. This evidence concerns the gene IGHE and asthma.