The results indicated that ERBB signaling pathway (normalized enrichment score, NES = -1.827, p.adj and FDR < 0.05), and JAK-STAT signaling pathway (NES = -2.054, p.adj and FDR < 0.05) were significantly down regulated in cluster 1 than that in cluster 2 (Figs. 4D and E, Supplementary Table 1), indicating that ERBB and JAK-STAT signaling pathways might play important roles in influencing the TIME of BC. Here, EGFR is linked to breast cancer.