The correlation analysis showed that among the common immune checkpoint-related genes, CD276 and CPSF3 had the highest correlation coefficient (Supplementary Table 2).To further validate the expression of CPSF3 in BC, the expression profiles from TCGA and GEO database (GSE 13507 and GSE 38264) were analyzed (Fig. 5C-E). The gene discussed is CPSF3; the disease is breast cancer.