In addition, higher TLN1 expression was significantly associated with poor prognosis in Brain Lower Grade Glioma, Adrenocortical carcinoma, Oral squamous Cell Carcinoma, Colon adenocarcinoma, Glioma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, indicating that TLN1 was a potential oncogene in these types of cancers (Supplementary Fig. 1A-F). Here, TLN1 is linked to central nervous system cancer.