As shown in Fig. 7A, both siRNA1 and siRNA2 could significantly reduce the expression of TLN1. Wright Giemsa compound staining results showed that silenced TLN1 leads to the transformation of AML cell nuclei from round to rod-shaped nuclei and paging nuclei and the nucleus of THP-1 appears pyknosis and deep staining (Fig. 7B). Here, TLN1 is linked to acute myeloid leukemia.