SOCS3 and cutaneous melanoma: Assuming the following candidate genes [CTSZ, EFEMP2, ITGA5, KDELR2, MAP2K3, MDK, MICALL2, PLAUR, SERPINE1, SOCS3], a tumor cohort including all skin cutaneous melanoma patients with somatic mutations aligned to GRCh38, and a healthy cohort including all donors having germline variants aligned to GRCh38, using VarSum we can easily compute the gene scores and their rank normalization, shown in Fig. 7.