Considering the relationship of CMBs and AD, the aims of this study were i) to investigate the influence of CMBs on the incidence of stroke and mortality, ii) to evaluate the impact of CMBs on the cognitive evolution of patients with mild-moderate AD, iii) to evaluate whether the number and localization of CMBs was associated with the cognitive decline of AD patients, and iv) to analyse the relationship of APOE genotype and CSF AD biomarkers to the presence and localization of CMBs. This evidence concerns the gene APOE and Alzheimer disease.