AKT1 and neoplasm: The largest portion of the differentially expressed transcripts after coral- versus macroalgal-DOM feeding in the HMA species P. angulospiculatus were related to several signaling pathways (Figs. 1 and 4A and Additional File 2), including mitogen-activated protein kinase (MAPK), Wnt/β-catenin, serine/threonine-protein kinase (AKT), p53, and Hippo signaling, which are related to developmental processes but also heavily involved in tumor development and metastasis in humans and mice.