The largest portion of the differentially expressed transcripts after coral- versus macroalgal-DOM feeding in the HMA species P. angulospiculatus were related to several signaling pathways (Figs. 1 and 4A and Additional File 2), including mitogen-activated protein kinase (MAPK), Wnt/β-catenin, serine/threonine-protein kinase (AKT), p53, and Hippo signaling, which are related to developmental processes but also heavily involved in tumor development and metastasis in humans and mice. The gene discussed is TP53; the disease is neoplasm.