MYCN and neuroblastoma: In contrast, while average methylation levels were lower in non-Cluster-2 samples, there was a stronger, statistically significant, correlation between cg11625005 methylation and expression (r = 0.5, P < 0.0001), suggesting methylation of this CpG site might be primarily of relevance in neuroblastoma that lacks MYCN amplification (Supplementary Fig. 5B).