Neuroblastoma has been classified into risk groups using multiple approaches, including the International Neuroblastoma Staging System (INSS), Children’s Oncology Group risk stratification (incorporating INSS and other clinical/genetic features, such as age of diagnosis and MYCN amplification) and the consensus International Neuroblastoma Risk group (INRG) classification system (which incorporates a pre-surgical staging system based on tumour imaging as opposed to surgical resection, as used in INSS) [3]. Here, MYCN is linked to neuroblastoma.