CALCOCO2 and infection: Using HeLa cells as a model, it was also determined that galectin-8 is a principal sensor of damaged endosomes and lysosomes after sterile injury as well as upon cell infection with S.typhimurium, L.monocytogenes, and S.flexneri, and galectin-8-dependent recruitment of an adaptor protein NDP52 activates autophagy, which limits pathogen burden inside infected cells51.