SPINK9 and hypothyroidism: Analysis of upregulated DEGs has shown that the following seven genes were common between all complications of TIDM (hyperlipidemia, neuropathy, ketoacidosis, hypothyroidism and PCOS): SPINK9, TRDN, PVRL4, MYO3A, PDLIM1, KIAA1614 and GRP (Fig. 6).