SPINK9 and hypothyroidism: Assessment of the relative fold-change of the seven upregulated genes in different T1DM complications showed a significant increase in expression of SPINK9 in T1DM complications compared to DWC, hyperlipidemia (5.28), neuropathy (3.79), ketoacidosis (5.20), hypothyroidism (3.79) and PCOS (5.20) (Table 4).