Involvement of MLKL in viral infection/response can be divided into two categories: RIPK3 mediated activation of MLKL (Vaccinia virus, Cytomegalovirus, Influenza virus) and MLKL direct targeting (BeAn 58058 poxivirus (BAV), Cotia Poxvirus (COTV) and human HCMV UL36) [84, 85]. This evidence concerns the gene MLKL and viral infectious disease.