We chose two cell lines, including the retinoblastoma cell line RB44 (Supplementary Data 1) and the human multiple myeloma cell line IM920 (Cancer Cell Line Encyclopedia, CCLE, https://sites.broadinstitute.org/ccle, COSMIC ID: 753563), as the non-mutation model of RB1 dysfunction. The gene discussed is RB1; the disease is AL amyloidosis.