Although we also found additional chromatin loop in HDF (human fibroblasts) control cells in intron 17 adjacent to exon 18 of the RB1 gene, but not in RB44 cells and retinoblastoma-specific RPE control cells (Supplementary Fig. 2), we thus focused on the E5-E7 looping. The gene discussed is RB1; the disease is retinoblastoma.