In addition, we found that tumor cells expressed higher levels of BMP2, N-cadherin, Vimentin and p-SMAD1/5 in the shLacZ group than in the shBMP2 group by IHC both in primary tumors (right lung) and metastatic tumors (left lung) (Fig. 6F and supplementary Fig. 7A,B). This evidence concerns the gene CDH2 and metastatic neoplasm.