In addition, we found that tumor cells expressed higher levels of BMP2, N-cadherin, Vimentin and p-SMAD1/5 in the shLacZ group than in the shBMP2 group by IHC both in primary tumors (right lung) and metastatic tumors (left lung) (Fig. 6F and supplementary Fig. 7A,B). The gene discussed is SMAD1; the disease is metastatic neoplasm.