Protective factors associated with non-progression phenotypes in the multivariate analyses were the initial EC-LTNP phenotype (HR = 0.59, 95% CI = 0.37–0.93; p = 2.4 × 10−2), the increase in both CD4 cell counts (HR = 0.30, 95% CI = 0.15–0.61; p = 9.1 × 10−4) and CD4/CD8 ratio (HR = 0.57, 95% CI = 0.37–0.88; p = 1.1 × 10−2) during follow-up, and HCV coinfection (HR = 0.54, 95% CI = 0.32–0.92; p = 2.4 × 10−2). Here, CD8A is linked to coinfection.